Abc ven là gì? Các công bố khoa học về Abc ven

To evaluate the efficacy of the Social ABCs parent‐mediated intervention for toddlers with suspected or confirmed autism spectrum disorder (ASD), through a cross‐site randomized control trial, sixty‐three parent–toddler dyads (toddler age: 16–30 months) were randomized into treatment (Social ABCs) or control (service‐as‐usual) conditions. Video data were obtained at three key time‐points: Baseline; Post‐training (PT; week 12); and Follow‐Up (week 24). Analyses included 62 dyads. Treatment allocation significantly accounted for PT gains, all favouring the Treatment group, in (1) child functional vocal responsiveness to parent prompts (R² = 0.43, P < .001), (2) child vocal initiations (R² = 0.28, P < .001), (3) parent smiling (R² = 0.09, P = .017), and (4) fidelity of implementation (R² = 0.71, P < .001). A trend was observed for increased social orienting (R² = 0.06, P = 0.054); gains in parent smiling significantly predicted increases in child smiling and social orienting. Parents in the treatment condition reported significant gains in self‐efficacy following the intervention (P = 0.009). No differential effects emerged for performance on standardized measures. The Social ABCs is a relatively low‐resource, efficacious intervention, with potential to be a cost‐effective means of intervening at the first signs of possible ASD. Autism Res 2017, 10: 1700–1711. © 2017 International Society for Autism Research, Wiley Periodicals, Inc.

Clinical Trial Title: Social ABCs for Toddlers with Signs of Autism Spectrum Disorder: RCT of a Parent‐Mediated Intervention http//ClinicalTrials.gov identifier: NCT02428452.

Oxysterols result from cholesterol by enzymatic or oxidative processes. Some exert cytotoxic effects leading to necrosis or apoptosis. Detoxification of these compounds mainly occurs in the liver and requires transport from peripheral tissues towards it. Some ATP‐binding cassette transporters are involved in export of cytotoxic compounds. In the current study, we investigated whether ABC transporter family member G1 (ABCG1) may be involved in oxysterol transport, since its gene expression is highly responsive to oxysterol loading. TetOff HeLa cells stably expressing ABCG1 showed decreased mass uptake of 7β‐hydroxycholesterol (7β‐HC) whereas that of other physiologically relevant oxysterols was unaffected. Application of 7β‐HC to ABCG1 expressing cells induced hyperpolarization of mitochondrial membrane potential and production of reactive oxygen species, indicating energy consumption by the ATP‐binding cassette transporter when it is activated by its correct substrate. Our study points to detoxification as one of potential cellular functions of ABCG1. We assume that ABCG1 protects against 7β‐HC‐induced cell death, an important role in prevention of neurodegenerative and cardiovascular disease.